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Symptoms can come and go and severity can also vary.

The symptoms are generally worse in the evening and at night.

For some people, symptoms may cause severe nightly sleep disruption that can significantly impair their quality of life. It affects both sexes, but is more common in women and may begin at any age, even in young children.

Restless legs syndrome may affect up to 10% of the U. Most people who are affected severely are middle-aged or older. This is especially true if the symptoms are intermittent or mild.

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The severity of RLS symptoms ranges from mild to intolerable.

Trazodone's hypnotic properties are due to its antihistaminergic effects at the histamine-1 receptor, alpha 1-adrenergic receptor antagonism, and serotonin 5-HT2 receptor antagonism.

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However, at week 2 zolpidem shortened time to fall asleep greater than trazodone.

Trazodone versus Quetiapine (Seroquel®) The observational study compared and contrasted the efficacy of trazodone and quetiapine (Seroquel), an atypical antipsychotic, for insomnia in persons with with mental illness.

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